Dosulepin has a toxic profile and hence needs to be taken under medical supervision, The dosage regimen is oral administration of drug initially 25mg tid with a gradual increase to 50 mg tid, if need be the dose might be adjusted as a single dose of 225mg/day at night in cases of severe depression. Major depressive disorders currently reigning the largest market share in the dosulepin market. In this disease, the patient experiences low mood for at least 2 weeks which is usually accompanies by low self-esteem, lethargy, neuropsychic pain,…

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